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Reliance on Prothrombin Time Ratios Causes Significant Errors in Anticoagulation Therapy Arch Int Med 152:278-282, 2571992., Bussey,H.I.,et al, 1992 See this aricle in Pubmed Article Abstract Of 53 laboratories surveyed,16(30%)could not provide ISI data and only 11 (21%)reported INR results.Unlabeled thromboplastin was being used by 20%to 24%of laboratories,and only 8%to 20%were using thromboplastins with an ISI of 2.2 to 2.6.At the time the three manufacturers were contacted,they reported marketing thromboplastins with ISI values from 1.2 to 2.8,but none of the thromboplastins at that time had ISI values between 2.2 and 2. 6.Warfarin therapy in the United States is managed inappropriately because most laboratories do not report INRs and the variability in thromboplastin sensitivity produces misleading prothrombin time ratio results. Additionally,recent research may require reexamination if INR or ISI data were not provided.

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(click to filter results - removes previous filter) anticoagulant,complications of anticoagulant,treatment laboratory values,normal prothrombin time

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